The Function of Connection: A Qualitative Examination of Social-Ecological Supports in the Lives of Parentally Bereaved Youth

The Function of Connection: A Qualitative Examination of Social-Ecological Supports in the Lives of Parentally Bereaved Yout

Relations between Maternal Personality, Parenting, and Toddlers’ Emotion Regulation and Externalizing Behaviors

This study examined relations between maternal personality, parenting behavior, and young children’s emotion regulation and externalizing behaviors. More specifically, the study examined whether parenting behavior mediated or moderated associations between maternal personality and children’s distress during a frustration-eliciting task or associations between maternal personality and children’s externalizing behaviors. Participants included 95 typically developing 24-month-olds and their mothers. Maternal sensitivity was evaluated during a mother-child structured interaction in the laboratory. In a separate laboratory task, children’s access to a treat was prevented in order to assess children’s distress. Data on externalizing behavior problems and maternal personality were collected using questionnaires completed by mothers. Multiple dimensions of maternal personality were related to children’s externalizing problems, but maternal sensitivity did not mediate these associations. However, maternal sensitivity did moderate the relationship between the maternal personality factor of agreeableness and children’s externalizing problems: Maternal agreeableness was positively related to externalizing problems but only when mothers were relatively low in sensitivity

Geotechnical Data and Numerical Analysis of Edifice Collapse and Related Hazards at Pacaya Volcano, Guatemala

The continual eruptive activity, occurrence of an ancestral catastrophic collapse, and inherent geologic features of Pacaya volcano (Guatemala) demands an evaluation of potential collapse hazards. This thesis merges techniques in the field and laboratory for a better rock mass characterization of volcanic slopes and slope stability evaluation. New field geological, structural, rock mechanical and geotechnical data on Pacaya is reported and is integrated with laboratory tests to better define the physical-mechanical rock mass properties. Additionally, this data is used in numerical models for the quantitative evaluation of lateral instability of large sector collapses and shallow landslides. Regional tectonics and local structures indicate that the local stress regime is transtensional, with an ENE-WSW sigma 3 stress component. Aligned features trending NNW-SSE can be considered as an expression of this weakness zone that favors magma upwelling to the surface. Numerical modeling suggests that a large-scale collapse could be triggered by reasonable ranges of magma pressure (greater than or equal to 7.7 MPa if constant along a central dyke) and seismic acceleration (greater than or equal to 460 cm/s2), and that a layer of pyroclastic deposits beneath the edifice could have been a factor which controlled the ancestral collapse. Finally, the formation of shear cracks within zones of maximum shear strain could provide conduits for lateral flow, which would account for long lava flows erupted at lower elevations

Using Blogs to Foster Inquiry, Collaboration, and Feedback in Pre-Service Teacher Education

This chapter presents a critical case study on the use of information technology in a pre-service teacher education program. The authors integrated Weblogs (blogs) into two constructivist-oriented teacher preparation courses with the goal of helping students learn to think like a teacher through enhanced inquiry, collaboration, and feedback. The authors found that, through the use of blogs, pre-service teaching candidates grew in their abilities to reflect on their own teaching and to provide constructive comments to peers. The authors’ experience also indicated that while instructor and peer feedback via blogs was valuable, it functioned best when paired with face-to-face meetings between the instructors and students. They discussed design principles for combining online and face-to-face environments and offer possibilities for the expanded use of blogs in pre-service teacher education

Post-eruption deformation processes measured using ALOS-1 and UAVSAR InSAR at Pacaya Volcano, Guatemala

Pacaya volcano is a persistently active basaltic cone complex located in the Central American Volcanic Arc in Guatemala. In May of 2010, violent Volcanic Explosivity Index-3 (VEI-3) eruptions caused significant topographic changes to the edifice, including a linear collapse feature 600 m long originating from the summit, the dispersion of ~20 cm of tephra and ash on the cone, the emplacement of a 5.4 km long lava flow, and ~3 m of co-eruptive movement of the southwest flank. For this study, Interferometric Synthetic Aperture Radar (InSAR) images (interferograms) processed from both spaceborne Advanced Land Observing Satellite-1 (ALOS-1) and aerial Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) data acquired between 31 May 2010 and 10 April 2014 were used to measure post-eruptive deformation events. Interferograms suggest three distinct deformation processes after the May 2010 eruptions, including: (1) subsidence of the area involved in the co-eruptive slope movement; (2) localized deformation near the summit; and (3) emplacement and subsequent subsidence of about a 5.4 km lava flow. The detection of several different geophysical signals emphasizes the utility of measuring volcanic deformation using remote sensing techniques with broad spatial coverage. Additionally, the high spatial resolution of UAVSAR has proven to be an excellent compliment to satellite data, particularly for constraining motion components. Measuring the rapid initiation and cessation of flank instability, followed by stabilization and subsequent influence on eruptive features, provides a rare glimpse into volcanic slope stability processes. Observing these and other deformation events contributes both to hazard assessment at Pacaya and to the study of the stability of stratovolcanoes

Geomechanical rock properties of a basaltic volcano

In volcanic regions, reliable estimates of mechanical properties for specific volcanic events such as cyclic inflation-deflation cycles by magmatic intrusions, thermal stressing, and high temperatures are crucial for building accurate models of volcanic phenomena. This study focuses on the challenge of characterizing volcanic materials for the numerical analyses of such events. To do this, we evaluated the physical (porosity, permeability) and mechanical (strength) properties of basaltic rocks at Pacaya Volcano (Guatemala) through a variety of laboratory experiments, including: room temperature, high temperature (935 °C), and cyclically-loaded uniaxial compressive strength tests on as-collected and thermally-treated rock samples. Knowledge of the material response to such varied stressing conditions is necessary to analyze potential hazards at Pacaya, whose persistent activity has led to 13 evacuations of towns near the volcano since 1987. The rocks show a non-linear relationship between permeability and porosity, which relates to the importance of the crack network connecting the vesicles in these rocks. Here we show that strength not only decreases with porosity and permeability, but also with prolonged stressing (i.e., at lower strain rates) and upon cooling. Complimentary tests in which cyclic episodes of thermal or load stressing showed no systematic weakening of the material on the scale of our experiments. Most importantly, we show the extremely heterogeneous nature of volcanic edifices that arise from differences in porosity and permeability of the local lithologies, the limited lateral extent of lava flows, and the scars of previous collapse events. Input of these process-specific rock behaviors into slope stability and deformation models can change the resultant hazard analysis. We anticipate that an increased parameterization of rock properties will improve mitigation power

A Phase II Trial of Prexasertib (LY2606368) in Patients With Extensive-Stage Small-Cell Lung Cancer

Checkpoint kinase 1 inhibitor; Pharmacokinetics; Small cell lung cancerInhibidor de quinasa de punto de control 1; Farmacocinética; Cáncer de pulmón de células pequeñasInhibidor de la quinasa del punt de control 1; Farmacocinètica; Càncer de pulmó de cèl·lules petitesBackground This study assessed the checkpoint kinase 1 inhibitor prexasertib in patients with extensive-stage small-cell lung cancer (ED-SCLC). Patients and Methods This was a parallel-cohort phase II study of 105 mg/m2 prexasertib once every 14 days for patients who progressed after no more than two prior therapies and had platinum-sensitive (Cohort 1) or platinum-resistant/platinum-refractory (Cohort 2) disease. The primary endpoint was objective response rate (ORR). Secondary endpoints included disease control rate (DCR), progression-free survival (PFS), overall survival (OS), safety, and pharmacokinetics. Exploratory endpoints included biomarker identification and assessment of an alternative regimen (Cohort 3: 40 mg/m2 days 1-3, 14-day cycle). Results In Cohort 1 (n = 58), ORR was 5.2%; DCR, 31%; median PFS, 1.41 months (95% confidence interval [CI], 1.31-1.64); and median OS, 5.42 months (95% CI, 3.75-8.51). In Cohort 2 (n = 60), ORR was 0%; DCR, 20%; median PFS, 1.36 months (95% CI, 1.25-1.45); and median OS, 3.15 months (95% CI, 2.27-5.52). The most frequent all-grade, related, treatment-emergent adverse events were decreased neutrophil count (Cohort 1, 69.6%; Cohort 2, 73.3%), decreased platelet count (Cohort 1, 51.8%; Cohort 2, 50.0%), decreased white blood cell count (Cohort 1, 28.6%; Cohort 2, 40.0%), and anemia (Cohort 1, 39.3%; Cohort 2, 28.3%). Eleven patients (19.6%) in Cohort 1 and one patient (1.7%) in Cohort 2 experienced grade ≥3 febrile neutropenia. Prexasertib pharmacokinetics were consistent with prior studies. Cohort 3 outcomes were similar to those of Cohorts 1 and 2. No actionable biomarkers were identified. Conclusion Prexasertib did not demonstrate activity to warrant future development as monotherapy in ED-SCLC.This research was funded by Eli Lilly and Company